Pap12-6

£125.00 1mg

Antibacterial derived from the N-terminus of papiliocin.

Pap12-6 is an antibacterial peptide derived from the 12 amino acids in the N-terminus of papiliocin, a cecropin found in swallowtail butterfly larvae. Pap12-6 possesses broad-spectrum antibacterial activity, especially against multidrug-resistant Gram-negative bacteria, acting by permeabilizing the bacterial membrane. Pap12-6 significantly reduces the secretion of NO, TNF-?, and IL-6 and also shows anti-inflammatory activity via a TLR4-mediated NF-κB signaling pathway. In a mouse sepsis model, Pap12-6 significantly improved survival, reduced bacterial growth in organs, and reduced LPS and inflammatory cytokine levels.

SKU: AM-290 Categories: ,

Additional information

Three Letter Sequence

H-Arg-Trp-Lys-Ile-Phe-Lys-Lys-Val-Val-Lys-Lys-Trp-NH2

Molecular Weight

1645.11

Molecular Formula

C83H133N23O12

Sequence

RWKIFKKVVKKW-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

Pap12-6, RWKIFKKVVKKW-NH2, AM290, AM-290