Pancreatic Polypeptide (Human)
£175.00 1mg
Endogenous agonist for the human NPY Y4 receptor.
Pancreatic polypeptide (human) is an endogenous high affinity agonist for the human NPY Y4 receptor, with a Ki of 0.056 nM. Pancreatic polypeptide (human) is produced and secreted by PP cells of the pancreas which are primarily located in the Islets of Langerhans and is a member of the family of peptides that includes peptide YY (PYY) and neuropeptide Y (NPY). Pancreatic polypeptide (human) is rapidly released after a meal and in humans remains elevated for 4-6 hours, with the vagus nerve being the major stimulator. Pancreatic polypeptide (human) causes a sustained decrease in both appetite and food intake.
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Additional information
| Other Names | Pancreatic polypeptide, PP |
|---|---|
| Three Letter Sequence | H-Ala-Pro-Leu-Glu-Pro-Val-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Asp-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 |
| Molecular Weight | 4181.7 |
| Molecular Formula | C185H287N53O54S2 |
| Sequence | APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-NH2 |
| Solubility | Soluble to 0.70 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% |
| Modifications | C-terminal amide |
| Searchable Words | Pancreatic polypeptide (human), 75976-10-2, APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-NH2, APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY |