PAMP 20 (human)
£125.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Endogenous MRGPRX2 agonist.
PAMP 20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2) with an EC50 of 251 nM. PAMP 20, or proadrenomedullin N-terminal 20 peptide, is liberated from proadrenomedullin by proteolytic cleavage and is a potent hypotensive and catecholamine release inhibitory peptide. PAMP 20 (human) displays potent antimicrobial activity against standard bacterial strains, with a mechanism of action not involving the microbial cell membrane but instead targeting binding to bacterial DNA.
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Additional information
| Other Names | Proadrenomedullin N-terminal 20 peptide, PAMP (1-20) |
|---|---|
| Three Letter Sequence | H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 |
| Molecular Weight | 2460.87 |
| Molecular Formula | C112H178N36O27 |
| Sequence | ARLDVASEFRKKWNKWALSR-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide |
| Searchable Words | PAMP-20 (human), PAMP 20 (human), MG-020, 150238-87-2, ARLDVASEFRKKWNKWALSR-NH2, ARLDVASEFRKKWNKWALSR, Proadrenomedullin N-terminal 20 peptide, PAMP (1-20) |