PAMP 20 (Human)

£125.00 1mg

Endogenous MRGPRX2 agonist.

PAMP 20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2) with an EC50 of 251 nM. PAMP 20, or proadrenomedullin N-terminal 20 peptide, is liberated from proadrenomedullin by proteolytic cleavage and is a potent hypotensive and catecholamine release inhibitory peptide. PAMP 20 (human) displays potent antimicrobial activity against standard bacterial strains, with a mechanism of action not involving the microbial cell membrane but instead targeting binding to bacterial DNA.

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SKU: MG-020 Categories: ,

Additional information

Other Names

Proadrenomedullin N-terminal 20 peptide, PAMP (1-20)

Three Letter Sequence

H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2

Molecular Weight

2460.87

Molecular Formula

C112H178N36O27

Sequence

ARLDVASEFRKKWNKWALSR-NH2

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide

Searchable Words

PAMP-20 (human), PAMP 20 (human), MG-020, 150238-87-2, ARLDVASEFRKKWNKWALSR-NH2, ARLDVASEFRKKWNKWALSR, Proadrenomedullin N-terminal 20 peptide, PAMP (1-20)