PAMP 20 (Human)
£125.00 1mg
Endogenous MRGPRX2 agonist.
PAMP 20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2) with an EC50 of 251 nM. PAMP 20, or proadrenomedullin N-terminal 20 peptide, is liberated from proadrenomedullin by proteolytic cleavage and is a potent hypotensive and catecholamine release inhibitory peptide. PAMP 20 (human) displays potent antimicrobial activity against standard bacterial strains, with a mechanism of action not involving the microbial cell membrane but instead targeting binding to bacterial DNA.
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Additional information
| Other Names | Proadrenomedullin N-terminal 20 peptide, PAMP (1-20) |
|---|---|
| Three Letter Sequence | H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 |
| Molecular Weight | 2460.87 |
| Molecular Formula | C112H178N36O27 |
| Sequence | ARLDVASEFRKKWNKWALSR-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide |
| Searchable Words | PAMP-20 (human), PAMP 20 (human), MG-020, 150238-87-2, ARLDVASEFRKKWNKWALSR-NH2, ARLDVASEFRKKWNKWALSR, Proadrenomedullin N-terminal 20 peptide, PAMP (1-20) |