PAMP 12 (Human, Porcine)

£85.00 1mg

Endogenous MRGPRX2 agonist.

PAMP 12 (human, porcine) corresponds to amino acids 9 to 20 of proadrenomedullin and is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2) with an EC50 of 57.2 nM. PAMP 12 (human, porcine) can cause hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. PAMP 12 (human, porcine) displays potent antimicrobial activity against standard bacterial strains, with a mechanism of action not involving the microbial cell membrane but instead targeting binding to bacterial DNA.

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SKU: MG-010 Categories: ,

Additional information

Other Names

PAMP (9-20)

Three Letter Sequence

H-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2

Molecular Weight

1618.95

Molecular Formula

C77H119N25O14

Sequence

FRKKWNKWALSR-NH2

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide

Searchable Words

PAMP-12 (human, porcine), PAMP 12, MG-010, 196305-05-2, FRKKWNKWALSR-NH2, FRKKWNKWALSR, PAMP (9-20)