Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

GPR133 activator.

p13 is a peptide derived from the C-terminal component which starts at the GPCR proteolysis cleavage site of GPR133. p13 specifically activates both generated chimeric P2Y12-CTF(GPR133) receptors and the wild-type GPR133 ?receptor and is an agonist as measured by cAMP accumulation. p13 is highly selective for GPR133, and is a short tethered sequence (the Stachel sequence) within the ectodomain of GPR133, reinforcing that tethered peptide activation is a common signalling modality for the adhesion GPCR class of receptors.

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