Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Hormone which can suppress food intake.

Similarly to ghrelin, obestatin is derived from the proteolytic cleavage of proghrelin and binds to the orphan G protein-coupled receptor GPR39 to suppress food intake, inhibit jejunal contraction and decrease body-weight gain in rats, contrary to the appetite-stimulating effects of ghrelin. Thus two peptide hormones with opposing action in weight regulation are derived from the same ghrelin gene.

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