Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Ubiquitin isopeptidase inhibitor.

NSC 632839, also known as F6, targets the ubiquitin-proteasome system by inhibiting ubiquitin isopeptidases. NSC 632839 is able to activate an apoptosome-independent apoptotic pathway which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, and also the involvement of the death receptor pathway.

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