NNGH

£55.00 5mg

SKU: PI-060 Categories: ,

Matrix metalloproteinase 3 (MMP-3) inhibitor.

NNGH is a potent and cell-permeable inhibitor of matrix metalloproteinase 3 (MMP-3, stromelysin 1, progelatinase). Inhibition of MMP-3 with NNGH significantly suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of NF-KB, AP-1, and MAPK in LPS-stimulated microglia, suggesting a role for MMP-3 in neuroinflammation. NNGH additionally shows broad spectrum inhibition activity at other MMPs and is cell permeable.

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Additional information

Three Letter Sequence

N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic acid

Molecular Weight

316.37

Molecular Formula

C13H20N2O5S

Sequence

N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic acid

Solubility

Soluble in DMSO to 100 mM and in ethanol to 25 mM

Appearance

Off white solid

Storage

Store desiccated, frozen and in the dark

Purity

>98%