NFAT Inhibitor

£85.00 1mg

Calcineurin-NFAT interaction inhibitor.

NFAT inhibitor is a high affinity calcineurin binding peptide which acts as a selective inhibitor of the interaction of calcineurin with the transcription factor nuclear factor of activated T cells (NFAT), which it does without affecting calcineurin phosphatase activity or non-NFAT-mediated signalling. Activation of NFAT by calcineurin is a key step in T cell activation and accordingly, NFAT inhibitor peptide blocks NFAT activation and NFAT dependent expression of endogenous T cell cytokine genes. ? Other cytokines that require calcineurin but not NFAT are not affected. NFAT inhibition by NFAT inhibitor peptide is an effective strategy to quench inflammation and hypertrophy.

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SKU: PP-240 Categories: ,

Additional information

Other Names

VIVIT peptide, VIVIT-16

Three Letter Sequence

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

Molecular Weight

1684.06

Molecular Formula

C75H118N20O22S

Sequence

MAGPHPVIVITGPHEE

Solubility

Soluble to 2 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

NFAT Inhibitor, PP-240, PP240, VIVIT peptide, 249537-73-3, MAGPHPVIVITGPHEE, VIVIT-16