Neurokinin B (Human, Porcine)

£125.00 1mg

SKU: TK-010 Categories: ,

NK3 selective endogenous tachykinin agonist.

Neurokinin B (human, porcine) is a tachykinin agonist peptide that shows preference for the NK3 receptor, with an EC50 of 1 nM. Neurokinin B (human, porcine) is an important endogenous neuropeptide and contributes to luteinizing hormone secretion, the estrous cycle, energy balance, dynamics of fetus in placenta, and contraction in uterine muscles of rat. Loss of function mutations in the genes encoding either neurokinin B or its receptor, NK3 result in hypogonadotropic hypogonadism, implicating NKB and NK3 as essential elements of the human reproductive axis.

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Additional information

Other Names

NKB

Three Letter Sequence

H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2

Molecular Weight

1210.43

Molecular Formula

C55H79N13O14S2

Sequence

DMHDFFVGLM-NH2

Solubility

Soluble to 1 mg/ml in DMSO

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide

Searchable Words

Neurokinin B (human, porcine), 86933-75-7, DMHDFFVGLM, DMHDFFVGLM-NH2