Nelfinavir Mesylate

£65.00 10mg

Human immunodeficiency virus (HIV)-1 protease inhibitor.

Nelfinavir, also known as AG 1343, is a potent human immunodeficiency virus (HIV)-1 protease inhibitor with a Ki of 2 nM in vitro. Nelfinavir also displays broad spectrum anticancer activity and can inhibit the growth of cancer cells and trigger apoptosis. Nelfinavir has two main mechanisms of cancer cell growth inhibition, inhibition of the Akt/PKB signaling pathway and activation of endoplasmic reticulum stress with subsequent unfolded protein response. Nelfinavir also displays efficacy against malaria, tuberculosis and SARS and exhibits anti-MERS-CoV activity in vero cells in vitro.

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SKU: CV-040 Categories: ,

Additional information

Other Names

AG 1343

Three Letter Sequence

(3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy- 2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate

Molecular Weight

663.9

Molecular Formula

C32H45N3O4S. CH3SO3H

Sequence

(3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy- 2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate

Solubility

Soluble in DMSO to 70mg/ml

Appearance

White powder

Storage

Store dessicated, frozen and in the dark

Purity

>98% by HPLC; NMR conforms to structure