Myr-tat-CBD3

£185.00 1mg

Blocks the ? CaV2.2 ?CRMP2 interaction.

Myr-tat-CBD3 is the N-terminal myristoylated version of TAT-CBD3 (PN-160), a peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2). The myristoyl group allows insertion of myr-tat-CBD3 into membranes through hydrophobic interactions and myr-tat-CBD3 is membrane tethered, restricts the CaV2.2 ?CRMP2 interaction, blocks CaV2.2 trafficking, and strongly inhibits Ca2+ influx from primary sensory neurons. Intrathecal injection of myr-tat-CBD3 reduces carrageenan-induced inflammation and reverses paw incision induced thermal and mechanical hypersensitivity without producing rewarding behaviour.

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SKU: PP-180 Categories: ,

Additional information

Three Letter Sequence

Myr-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Ala-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH

Molecular Weight

3459.2

Molecular Formula

C148H269N59O33

Sequence

Myr-YGRKKRRQRRRARSRLAELRGVPRGL

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

Myristoyl at N terminal

Searchable Words

Myr-tat-CBD3, N-terminal myristoylated version of TAT-CBD3, axonal collapsin response mediator protein 2, CRMP-2), CaV2.2 “CRMP2 interaction, PP-180