Myr-tat-CBD3
£185.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Blocks the ? CaV2.2 ?CRMP2 interaction.
Myr-tat-CBD3 is the N-terminal myristoylated version of TAT-CBD3 (PN-160), a peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2). The myristoyl group allows insertion of myr-tat-CBD3 into membranes through hydrophobic interactions and myr-tat-CBD3 is membrane tethered, restricts the CaV2.2 ?CRMP2 interaction, blocks CaV2.2 trafficking, and strongly inhibits Ca2+ influx from primary sensory neurons. Intrathecal injection of myr-tat-CBD3 reduces carrageenan-induced inflammation and reverses paw incision induced thermal and mechanical hypersensitivity without producing rewarding behaviour.
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Additional information
| Three Letter Sequence | Myr-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Ala-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH |
|---|---|
| Molecular Weight | 3459.2 |
| Molecular Formula | C148H269N59O33 |
| Sequence | Myr-YGRKKRRQRRRARSRLAELRGVPRGL |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Myristoyl at N terminal |
| Searchable Words | Myr-tat-CBD3, N-terminal myristoylated version of TAT-CBD3, axonal collapsin response mediator protein 2, CRMP-2), CaV2.2 “CRMP2 interaction, PP-180 |