Myr-tat-CBD3
£185.00 1mg
Blocks the ? CaV2.2 ?CRMP2 interaction.
Myr-tat-CBD3 is the N-terminal myristoylated version of TAT-CBD3 (PN-160), a peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2). The myristoyl group allows insertion of myr-tat-CBD3 into membranes through hydrophobic interactions and myr-tat-CBD3 is membrane tethered, restricts the CaV2.2 ?CRMP2 interaction, blocks CaV2.2 trafficking, and strongly inhibits Ca2+ influx from primary sensory neurons. Intrathecal injection of myr-tat-CBD3 reduces carrageenan-induced inflammation and reverses paw incision induced thermal and mechanical hypersensitivity without producing rewarding behaviour.
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Additional information
| Three Letter Sequence | Myr-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Ala-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH |
|---|---|
| Molecular Weight | 3459.2 |
| Molecular Formula | C148H269N59O33 |
| Sequence | Myr-YGRKKRRQRRRARSRLAELRGVPRGL |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Myristoyl at N terminal |
| Searchable Words | Myr-tat-CBD3, N-terminal myristoylated version of TAT-CBD3, axonal collapsin response mediator protein 2, CRMP-2), CaV2.2 “CRMP2 interaction, PP-180 |