Multi-Leu Peptide

£99.00 1mg

PACE4 inhibitor.

Multi-Leu peptide is a peptide identified from a partial combinatorial library that is selective for the proprotein convertase PACE4, notably being 20 fold selective over furin, a closely related enzyme with similar structural characteristics. Proprotein convertases play an important role in protein precursor activation through processing at paired basic residues and PACE4 specifically has an important role in prostate cancer. Consistent with inhibition of PACE4, Multi-Leu peptide significantly reduces the proliferation of DU145 and LNCaP prostate cancer derived cell lines and induces G0/G1 cell cycle arrest.

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SKU: PI-290 Categories: ,

Additional information

Other Names

ML-peptide, Multi-Leucine (ML)-peptide

Three Letter Sequence

Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2

Molecular Weight

1050.74

Molecular Formula

C49H94N16O9

Sequence

Ac-LLLLRVKR-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N terminal acetyl, C terminal amide

Searchable Words

Multi-leu peptide, PI-290, PI290, Ac-LLLLRVKR-NH2, ML-peptide, Multi-Leucine (ML)-peptide, ml peptide