MOTS-c

£125.00 1mg

AMPK activator.

MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame (sORF) within the mitochondrial 12S RNA. MOTS-c, which is a contraction of mitochondrial open reading frame of the 12S rRNA-c, regulates insulin sensitivity and metabolic homeostasis with its primary target organ being skeletal muscle. The cellular action of MOTS-c is to inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to activation of AMP-activated protein kinase (AMPK), a central regulator of energy homeostasis. In mouse models, MOTS-c treatment prevents age dependent and high fat diet-induced insulin resistance, as well as diet induced obesity.

Please contact us for availability.

SKU: KS-210 Categories: ,

Additional information

Other Names

Mitochondria-derived peptide MOTS-c, Mitochondrial open reading frame of the 12S rRNA-c

Three Letter Sequence

H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH

Molecular Weight

2174.62

Molecular Formula

C101H152N28O22S2

Sequence

MRWQEMGYIFYPRKLR

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

MOTS-c, KS-210, KS210, Mitochondria-derived peptide MOTS-c, MRWQEMGYIFYPRKLR, 627580-64-6, Mitochondrial open reading frame of the 12S rRNA-c