MLCK Inhibitor Peptide 18

£65.00 1mg

Selective inhibitor of myosin light chain kinase.

MLCK inhibitor peptide 18 is a selective cell permeable inhibitor of myosin light chain kinase with an IC50 of 50 nM. MLCK inhibitor peptide 18 displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. In vitro and in vivo treatment with the MLCK inhibitor peptide 18 attenuates the increased epithelial monolayer permeability and occludin endocytosis caused by intestinal anoxia/reoxygenation (A/R) injury.

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SKU: KS-180 Categories: ,

Additional information

Other Names

Myosin Light Chain Kinase Inhibitor Peptide 18, Peptide 18

Three Letter Sequence

H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2

Molecular Weight

1324.64

Molecular Formula

C60H105N23O11

Sequence

RKKYKYRRK-NH2

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide

Searchable Words

MLCK inhibitor peptide 18, 224579-74-2