MG 132

£65.00 5mg

SKU: PI-030 Categories: , ,

Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Inhibits the chymotrypsin like activity of the 20S proteasome.

MG 132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome with an IC50 of 100 nM with Z-LLL-AMC as the substrate. MG 132 also inhibits calpain, suppresses gastric cancer cell proliferation and induces macro-autophagy. It also inhibits TNF-?-induced NF-κB activation and IκB? degradation and induces neurite outgrowth in PC12 cells. MG 132 inhibits SARS-CoV-2 Mpro in vitro and can inhibit viral replication.

Please contact us for availability.

Additional information

Other Names

Z-LLL-al, Z-Leu-Leu-Leu-CHO

Three Letter Sequence

Z-Leu-Leu-Leu-CHO

Molecular Weight

475.63

Molecular Formula

C26H41N3O5

Sequence

Z-LLL-CHO

Solubility

Dissolves in DMSO (45 mg/mL) or ethanol (45 mg/mL)

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>98% by HPLC

Modifications

N-terminal N-[(Phenylmethoxy)carbonyl, Leucine 3 is leucinal

Searchable Words

MG 132, Z-Leu-Leu-Leu-CHO, Z-LLL-al, 133407-82-6, chymotrypsin-like activity, 20S proteasome, calpain, 133407-82-6, PI-030, PI030