MG 132
£65.00 5mg
Inhibits the chymotrypsin like activity of the 20S proteasome.
MG 132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome with an IC50 of 100 nM with Z-LLL-AMC as the substrate. MG 132 also inhibits calpain, suppresses gastric cancer cell proliferation and induces macro-autophagy. It also inhibits TNF-?-induced NF-κB activation and IκB? degradation and induces neurite outgrowth in PC12 cells. MG 132 inhibits SARS-CoV-2 Mpro in vitro and can inhibit viral replication.
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Additional information
| Other Names | Z-LLL-al, Z-Leu-Leu-Leu-CHO |
|---|---|
| Three Letter Sequence | Z-Leu-Leu-Leu-CHO |
| Molecular Weight | 475.63 |
| Molecular Formula | C26H41N3O5 |
| Sequence | Z-LLL-CHO |
| Solubility | Dissolves in DMSO (45 mg/mL) or ethanol (45 mg/mL) |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >98% by HPLC |
| Modifications | N-terminal N-[(Phenylmethoxy)carbonyl, Leucine 3 is leucinal |
| Searchable Words | MG 132, Z-Leu-Leu-Leu-CHO, Z-LLL-al, 133407-82-6, chymotrypsin-like activity, 20S proteasome, calpain, 133407-82-6, PI-030, PI030 |