MG 132

£65.00 5mg

Inhibits the chymotrypsin like activity of the 20S proteasome.

MG 132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome with an IC50 of 100 nM with Z-LLL-AMC as the substrate. MG 132 also inhibits calpain, suppresses gastric cancer cell proliferation and induces macro-autophagy. It also inhibits TNF-?-induced NF-κB activation and IκB? degradation and induces neurite outgrowth in PC12 cells. MG 132 inhibits SARS-CoV-2 Mpro in vitro and can inhibit viral replication.

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SKU: PI-030 Categories: ,

Additional information

Other Names

Z-LLL-al, Z-Leu-Leu-Leu-CHO

Three Letter Sequence

Z-Leu-Leu-Leu-CHO

Molecular Weight

475.63

Molecular Formula

C26H41N3O5

Sequence

Z-LLL-CHO

Solubility

Dissolves in DMSO (45 mg/mL) or ethanol (45 mg/mL)

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>98% by HPLC

Modifications

N-terminal N-[(Phenylmethoxy)carbonyl, Leucine 3 is leucinal

Searchable Words

MG 132, Z-Leu-Leu-Leu-CHO, Z-LLL-al, 133407-82-6, chymotrypsin-like activity, 20S proteasome, calpain, 133407-82-6, PI-030, PI030