MG 132
£65.00 5mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Inhibits the chymotrypsin like activity of the 20S proteasome.
MG 132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome with an IC50 of 100 nM with Z-LLL-AMC as the substrate. MG 132 also inhibits calpain, suppresses gastric cancer cell proliferation and induces macro-autophagy. It also inhibits TNF-?-induced NF-κB activation and IκB? degradation and induces neurite outgrowth in PC12 cells. MG 132 inhibits SARS-CoV-2 Mpro in vitro and can inhibit viral replication.
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Additional information
Other Names | Z-LLL-al, Z-Leu-Leu-Leu-CHO |
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Three Letter Sequence | Z-Leu-Leu-Leu-CHO |
Molecular Weight | 475.63 |
Molecular Formula | C26H41N3O5 |
Sequence | Z-LLL-CHO |
Solubility | Dissolves in DMSO (45 mg/mL) or ethanol (45 mg/mL) |
Appearance | Freeze dried solid |
Storage | Store desiccated, frozen and in the dark |
Purity | >98% by HPLC |
Modifications | N-terminal N-[(Phenylmethoxy)carbonyl, Leucine 3 is leucinal |
Searchable Words | MG 132, Z-Leu-Leu-Leu-CHO, Z-LLL-al, 133407-82-6, chymotrypsin-like activity, 20S proteasome, calpain, 133407-82-6, PI-030, PI030 |