MDL 28170
£65.00 10mg
Calpain and cathepsin B inhibitor.
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B with Ki values of 10 and 25 nM respectively, but does not have any effect on trypsin-like serine proteases. MDL 28170 rapidly penetrates the blood-brain barrier following systemic administration and demonstrates neuroprotective effects in vivo.
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Additional information
| Other Names | Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal |
|---|---|
| Three Letter Sequence | N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal |
| Molecular Weight | 382.45 |
| Molecular Formula | C22H26N2O4 |
| Sequence | Carbobenzoxy-VA-CHO |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | ‰¥95% (HPLC) |
| Modifications | N terminal is carbobenzoxy, phenylalanine is terminal aldehyde |
| Searchable Words | MDL 28170, calpain, cathepsin B, neuroprotective, 88191-84-8, Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal, PI-020, PI020 |