MDL 28170
£65.00 10mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Calpain and cathepsin B inhibitor.
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B with Ki values of 10 and 25 nM respectively, but does not have any effect on trypsin-like serine proteases. MDL 28170 rapidly penetrates the blood-brain barrier following systemic administration and demonstrates neuroprotective effects in vivo.
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Additional information
| Other Names | Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal |
|---|---|
| Three Letter Sequence | N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal |
| Molecular Weight | 382.45 |
| Molecular Formula | C22H26N2O4 |
| Sequence | Carbobenzoxy-VA-CHO |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | ‰¥95% (HPLC) |
| Modifications | N terminal is carbobenzoxy, phenylalanine is terminal aldehyde |
| Searchable Words | MDL 28170, calpain, cathepsin B, neuroprotective, 88191-84-8, Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal, PI-020, PI020 |