MDL 28170

£65.00 10mg

Calpain and cathepsin B inhibitor.

MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B with Ki values of 10 and 25 nM respectively, but does not have any effect on trypsin-like serine proteases. MDL 28170 rapidly penetrates the blood-brain barrier following systemic administration and demonstrates neuroprotective effects in vivo.

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SKU: PI-020 Categories: ,

Additional information

Other Names

Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal

Three Letter Sequence

N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal

Molecular Weight

382.45

Molecular Formula

C22H26N2O4

Sequence

Carbobenzoxy-VA-CHO

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

‰¥95% (HPLC)

Modifications

N terminal is carbobenzoxy, phenylalanine is terminal aldehyde

Searchable Words

MDL 28170, calpain, cathepsin B, neuroprotective, 88191-84-8, Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal, PI-020, PI020