Mca-YVADAP-K(Dnp)-OH
£125.00 1mg
FRET substrate for caspase-1.
Mca-YVADAP-K(Dnp)-OH, or Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, is a highly fluorescent FRET substrate for the determination of caspase-1 (ICE) and caspase-1-like enzyme activities. Cleavage of Mca-YVADAPK(Dnp)-OH at the P1 Asp residue results in a continuous fluorescent assay which can be monitored at an emission wavelength of 392 nm. Caspase-3 (apopain, CPP-32) is only weakly active on this substrate. Mca-YVADAP-K(Dnp)-OH is a specific substrate for renal ACE 2.
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Additional information
| Other Names | Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH |
|---|---|
| Three Letter Sequence | Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH |
| Molecular Weight | 1145.1 |
| Molecular Formula | C53H64N10O19 |
| Sequence | Mca-YVADAPK(Dnp) |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | 7-methoxycoumarin (Mca) at N terminal, 2,4-dintrophenyl on lysine 7 |
| Searchable Words | 189696-01-3, Mca-YVADAP-K(Dnp)-OH, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, fluorescent, FRET substrate, caspase-1, ICE, PS-030, PS030 |