Mca-YVADAP-K(Dnp)-OH

£125.00 1mg

FRET substrate for caspase-1.

Mca-YVADAP-K(Dnp)-OH, or Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, is a highly fluorescent FRET substrate for the determination of caspase-1 (ICE) and caspase-1-like enzyme activities. Cleavage of Mca-YVADAPK(Dnp)-OH at the P1 Asp residue results in a continuous fluorescent assay which can be monitored at an emission wavelength of 392 nm. Caspase-3 (apopain, CPP-32) is only weakly active on this substrate. Mca-YVADAP-K(Dnp)-OH is a specific substrate for renal ACE 2.

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SKU: PS-030 Categories: ,

Additional information

Other Names

Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH

Three Letter Sequence

Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH

Molecular Weight

1145.1

Molecular Formula

C53H64N10O19

Sequence

Mca-YVADAPK(Dnp)

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

7-methoxycoumarin (Mca) at N terminal, 2,4-dintrophenyl on lysine 7

Searchable Words

189696-01-3, Mca-YVADAP-K(Dnp)-OH, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, fluorescent, FRET substrate, caspase-1, ICE, PS-030, PS030