Mca-YVADAP-K(Dnp)-OH
£125.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
FRET substrate for caspase-1.
Mca-YVADAP-K(Dnp)-OH, or Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, is a highly fluorescent FRET substrate for the determination of caspase-1 (ICE) and caspase-1-like enzyme activities. Cleavage of Mca-YVADAPK(Dnp)-OH at the P1 Asp residue results in a continuous fluorescent assay which can be monitored at an emission wavelength of 392 nm. Caspase-3 (apopain, CPP-32) is only weakly active on this substrate. Mca-YVADAP-K(Dnp)-OH is a specific substrate for renal ACE 2.
Please contact us for availability.
Additional information
| Other Names | Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH |
|---|---|
| Three Letter Sequence | Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH |
| Molecular Weight | 1145.1 |
| Molecular Formula | C53H64N10O19 |
| Sequence | Mca-YVADAPK(Dnp) |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | 7-methoxycoumarin (Mca) at N terminal, 2,4-dintrophenyl on lysine 7 |
| Searchable Words | 189696-01-3, Mca-YVADAP-K(Dnp)-OH, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, fluorescent, FRET substrate, caspase-1, ICE, PS-030, PS030 |