Mca-SEVNLDAEFR-K(Dnp)-RR-NH2

£125.00 1mg

FRET substrate for beta-secretase 1 (BACE-1).

Mca-SEVNLDAEFR-K(Dnp)-RR-NH2, also knowm as Mca-(Asn ¶ · °,Leu ¶ · ¹)-Amyloid ?/A4 Protein Precursor ‚‡ ‚‡ ‚ (667-676)-Lys(Dnp)-Arg-Arg amide, is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the ‘Swedish’ Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) ?-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

Please contact us for availability.

SKU: PS-020 Categories: ,

Additional information

Other Names

Mca-(Asn ¶ · °,Leu ¶ · ¹)-Amyloid ?/A4 Protein Precursor ‚‡ ‚‡ ‚ (667-676)-Lys(Dnp)-Arg-Arg amide

Three Letter Sequence

Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2

Molecular Weight

2001.1

Molecular Formula

C86H125N27O29

Sequence

Mca-SEVNLDAEFR-K(Dnp)-RR-NH2

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

7-methoxycoumarin (Mca) at N terminal, 2,4-dintrophenyl on lysine 11, C terminal amide

Searchable Words

Mca-SEVNLDAEFR-K(Dnp)-RR-NH2, 438625-61-7, SEVNLDAEFRKRR, Mca-(Asn ¶ · °,Leu ¶ · ¹)-Amyloid ?/A4 Protein Precursor ‚‡ ‚‡ ‚ (667-676)-Lys(Dnp)-Arg-Arg amide, Beta-secretase 1, BACE-1, FRET substrate, Swedish Lys-Met/Asn-Leu mutation, fluorescent 7-methoxycoumarin, PS-020, PS020