Mca-RPPGFSAFK(Dnp)-OH
£125.00 1mg
FRET substrate for endothelin-converting enzyme-1 (ECE-1).
Mca-RPPGFSAFK(Dnp)-OH, also known as Mca-(Ala7,Lys(Dnp)9)-bradykinin is a very sensitive fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), the membrane-bound zinc metallopeptidase that is related to neprilysin. Mca-RPPGFSAFK(Dnp)-OH can also be used for assaying ACE1, ACE2, BACE, cathepsin A, cathepsin X/Z, ECE-1, ECE-2, MMP-2, MMP9, neprilysin, insulinase and thermolysin (TLN), although it is not a substrate for MMP1. Mca-RPPGFSAFK(Dnp)-OH substrate contains a highly fluorescent 7-methoxycoumarin (Mca) group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl (Dnp) group.
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Additional information
| Other Names | Mca-(Ala7,Lys(Dnp)9)-bradykinin |
|---|---|
| Three Letter Sequence | Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp) |
| Molecular Weight | 1388.5 |
| Molecular Formula | C66H81N15O19 |
| Sequence | Mca-RPPGFSAFK(Dnp) |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | 7-methoxycoumarin (Mca) at the N terminal, Lysine 9 has 2,4-dinitrophenyl (Dnp) attached |
| Searchable Words | 323577-36-2, Mca-RPPGFSAFK(Dnp)-OH, Mca-(Ala7,Lys(Dnp)9)-bradykinin, fluorescent substrate , endothelin-converting enzyme-1, ECE-1, zinc metallopeptidase, fluorescent 7-methoxycoumarin, Mca, 2,4-dinitrophenyl, Dnp) group, PS-050, PS050 |