Mca-RPPGFSAFK(Dnp)-OH
£125.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
FRET substrate for endothelin-converting enzyme-1 (ECE-1).
Mca-RPPGFSAFK(Dnp)-OH, also known as Mca-(Ala7,Lys(Dnp)9)-bradykinin is a very sensitive fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), the membrane-bound zinc metallopeptidase that is related to neprilysin. Mca-RPPGFSAFK(Dnp)-OH can also be used for assaying ACE1, ACE2, BACE, cathepsin A, cathepsin X/Z, ECE-1, ECE-2, MMP-2, MMP9, neprilysin, insulinase and thermolysin (TLN), although it is not a substrate for MMP1. Mca-RPPGFSAFK(Dnp)-OH substrate contains a highly fluorescent 7-methoxycoumarin (Mca) group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl (Dnp) group.
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Additional information
| Other Names | Mca-(Ala7,Lys(Dnp)9)-bradykinin |
|---|---|
| Three Letter Sequence | Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp) |
| Molecular Weight | 1388.5 |
| Molecular Formula | C66H81N15O19 |
| Sequence | Mca-RPPGFSAFK(Dnp) |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | 7-methoxycoumarin (Mca) at the N terminal, Lysine 9 has 2,4-dinitrophenyl (Dnp) attached |
| Searchable Words | 323577-36-2, Mca-RPPGFSAFK(Dnp)-OH, Mca-(Ala7,Lys(Dnp)9)-bradykinin, fluorescent substrate , endothelin-converting enzyme-1, ECE-1, zinc metallopeptidase, fluorescent 7-methoxycoumarin, Mca, 2,4-dinitrophenyl, Dnp) group, PS-050, PS050 |