Mca-RPKPVE-Nval-WR-K(Dnp)-NH2

£125.00 1mg

Fret substrate for MMP-3 and MMP-10.

Mca-RPKPVE-Nval-WRK(Dnp)-NH2, also known as Mca-RPKPVE-Nval-WRK(Dnp)-NH2 Fluorogenic MMP Substrate, is an excellent substrate for MMP-3 (stromelysin 1) and MMP-10 (stromelysin 2), but not a substrate MMP-1 or MMP-2. Mca-RPKPVE-Nval-WRK(Dnp)-NH2 substrate contains a highly fluorescent 7-methoxycoumarin (Mca) group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl (Dnp) group. The cleavage site is the peptide bond between Glu and Nval (norvaline). Mca-RPKPVE-Nval-WRK(Dnp)-NH2 is also an excellent substrate for trypsin, HGF activator and factor Xa.

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SKU: PS-040 Categories: ,

Additional information

Other Names

Mca-RPKPVE-Nval-WRK(Dnp)-NH2 fluorogenic MMP substrate

Three Letter Sequence

Mca-Arg-Pro-Lys-Pro-Val-Glu-Nval-Trp-Arg-Lys(Dnp)-NH2

Molecular Weight

1675.9

Molecular Formula

C78H110N22O20

Sequence

Mca-RPKPVEXWRK(Dnp)-NH2

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

7-methoxycoumarin (Mca) at the N terminal, X is norvaline, Lysine 10 is substuted with a 2,4-dinitrophenyl (Dnp) group, and the C terminal is amidated

Searchable Words

Mca-RPKPVE-Nval-WRK(Dnp)-NH2, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 Fluorogenic MMP Substrate, substrate, MMP-3 , stromelysin 1, stromelysin 2, 7-methoxycoumarin, Mca, 2,4-dinitrophenyl (Dnp), PS-040, PS040