LDN 57444
£75.00 10mg
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor.
LDN 57444 is an inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity with a Ki of 0.4 M. UCH-L1 is a deubiquitinating enzyme that is abundantly expressed in the brain, and its activity is required for normal synaptic function. Inhibition by LDN 57444 causes cell death through the apoptosis pathway, increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity.
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Additional information
| Three Letter Sequence | 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) |
|---|---|
| Molecular Weight | 397.64 |
| Molecular Formula | C17H11Cl3N2O3 |
| Sequence | 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) |
| Solubility | Soluble to 50 mM in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | ‰¥98% by HPLC |