LDN 57444

£75.00 10mg

Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor.

LDN 57444 is an inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity with a Ki of 0.4 M. UCH-L1 is a deubiquitinating enzyme that is abundantly expressed in the brain, and its activity is required for normal synaptic function. Inhibition by LDN 57444 causes cell death through the apoptosis pathway, increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity.

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SKU: PI-001 Categories: ,

Additional information

Three Letter Sequence

5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)

Molecular Weight

397.64

Molecular Formula

C17H11Cl3N2O3

Sequence

5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)

Solubility

Soluble to 50 mM in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

‰¥98% by HPLC