LAP
£175.00 1mg
Inhibits viral IRES mediated translation.
LAP (for La peptide) corresponds to amino acids 11 to 28 from the N-terminal La motif of La, a 52-kDa autoantigen found in patients with systemic lupus erythematosus, and one of the first cellular proteins identified to interact with viral internal ribosome entry site (IRES) elements and stimulate poliovirus (PV) and hepatitis C virus (HCV) IRES-mediated translation. LAP efficiently inhibits viral IRES-mediated translation in vitro. LAP does not bind RNA directly but blocks La binding to IRNA and PV 5′-UTR.
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Additional information
| Other Names | La peptide |
|---|---|
| Three Letter Sequence | H-Ala-Ala-Leu-Glu-Ala-Lys-Ile-Cys-His-Gln-Ile-Glu-Tyr-Tyr-Phe-Gly-Asp-Phe-NH2 |
| Molecular Weight | 2117.41 |
| Molecular Formula | C99H141N23O27S |
| Sequence | AALEAKICHQIEYYFGDF-NH2 |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | We recommend storage desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide |
| Searchable Words | LAP, La peptide, N-terminal La motif, systemic lupus erythematosus, viral internal ribosome entry site, IRES, poliovirus, hepatitis C, IRES-mediated translation, H-AALEAKICHQIEYYFGDF-NH2, AALEAKICHQIEYYFGDF-NH2, AM-190, AM190 |