LAP

£175.00 1mg

Inhibits viral IRES mediated translation.

LAP (for La peptide) corresponds to amino acids 11 to 28 from the N-terminal La motif of La, a 52-kDa autoantigen found in patients with systemic lupus erythematosus, and one of the first cellular proteins identified to interact with viral internal ribosome entry site (IRES) elements and stimulate poliovirus (PV) and hepatitis C virus (HCV) IRES-mediated translation. LAP efficiently inhibits viral IRES-mediated translation in vitro. LAP does not bind RNA directly but blocks La binding to IRNA and PV 5′-UTR.

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SKU: AM-190 Categories: ,

Additional information

Other Names

La peptide

Three Letter Sequence

H-Ala-Ala-Leu-Glu-Ala-Lys-Ile-Cys-His-Gln-Ile-Glu-Tyr-Tyr-Phe-Gly-Asp-Phe-NH2

Molecular Weight

2117.41

Molecular Formula

C99H141N23O27S

Sequence

AALEAKICHQIEYYFGDF-NH2

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

We recommend storage desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide

Searchable Words

LAP, La peptide, N-terminal La motif, systemic lupus erythematosus, viral internal ribosome entry site, IRES, poliovirus, hepatitis C, IRES-mediated translation, H-AALEAKICHQIEYYFGDF-NH2, AALEAKICHQIEYYFGDF-NH2, AM-190, AM190