KSL 128114
£195.00 1mg
Binds the PDZ1 domain of syntenin.
KSL 128114 is a potent, and metabolically stable peptide inhibitor of syntenin, which binds the PDZ1 domain of syntenin with nanomolar affinity. KSL 128114 is resistant toward degradation in human plasma and mouse hepatic microsomes and shows an inhibitory effect on primary glioblastoma cell viability. KSL 128114 significantly extends survival time in a patient derived glioblastoma xenograft mouse model.
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Additional information
| Three Letter Sequence | Ac-(D)Arg-Arg-(D)Arg-Gly-(D)Arg-Lys-(D)Lys-Arg-(D)Arg-Ser-His-Trp-Tle-Chg-Asp-Ile-OH |
|---|---|
| Molecular Weight | 2201.6 |
| Molecular Formula | C94H163N39O20 |
| Sequence | Ac-rRrGrKkRrSHW(Tle)(Chg)DI |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% |
| Modifications | N terminal is acetylated, arginines 1, 3, 5 and 9 and lysine 7 are D amino acids, Tle is tert butyl glycine and Chg is cyclohexylglycine |
| Searchable Words | KSL 128114, Ac-rRrGrKkRr-SHW(Tle)(Chg)DI, KSL-128114, KSL128114, PP-030 |