Kisspeptin 234
£85.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Kisspeptin receptor antagonist.
Kisspeptin 234 is an analogue of kisspeptin 10 which acts as a kisspeptin receptor antagonist. Of a series, kisspeptin 234 most potently inhibited kisspeptin 10 stimulation of inositol phosphate release in Chinese hamster ovarian cells stably expressing the human GPR54 with an IC50 of 7 nM. Intracerebroventricular administration of kisspeptin 234 causes delayed vaginal opening in rats (an indicator of puberty) and prevents an increase in circulating luteinising hormone concentration when co-administrated with kisspeptin 10.
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Additional information
| Other Names | Peptide 234, p234, K234 |
|---|---|
| Three Letter Sequence | Ac-(D)Ala-Asn-Trp-Asn-Gly-Phe-Gly-(D)Trp-Arg-Phe-NH2 |
| Molecular Weight | 1295.42 |
| Molecular Formula | C63H78N18O13 |
| Sequence | Ac-aNWNGFGwRF-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N-terminal acetyl, C-terminal amide; Ala-1 is D-Ala and Trp-8 is D-Trp |
| Searchable Words | Kisspeptin 234, 1145998-81-7, peptide 234, KR-010, KR010, Ac-aNWNGFGwRF-NH2, K234 |