Kisspeptin 234
£85.00 1mg
Kisspeptin receptor antagonist.
Kisspeptin 234 is an analogue of kisspeptin 10 which acts as a kisspeptin receptor antagonist. Of a series, kisspeptin 234 most potently inhibited kisspeptin 10 stimulation of inositol phosphate release in Chinese hamster ovarian cells stably expressing the human GPR54 with an IC50 of 7 nM. Intracerebroventricular administration of kisspeptin 234 causes delayed vaginal opening in rats (an indicator of puberty) and prevents an increase in circulating luteinising hormone concentration when co-administrated with kisspeptin 10.
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Additional information
| Other Names | Peptide 234, p234, K234 |
|---|---|
| Three Letter Sequence | Ac-(D)Ala-Asn-Trp-Asn-Gly-Phe-Gly-(D)Trp-Arg-Phe-NH2 |
| Molecular Weight | 1295.42 |
| Molecular Formula | C63H78N18O13 |
| Sequence | Ac-aNWNGFGwRF-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N-terminal acetyl, C-terminal amide; Ala-1 is D-Ala and Trp-8 is D-Trp |
| Searchable Words | Kisspeptin 234, 1145998-81-7, peptide 234, KR-010, KR010, Ac-aNWNGFGwRF-NH2, K234 |