KGYY15

£125.00 1mg

Interacts with CD40.

KGYY15 is a peptide derived from amino acids 136 to 150 of the mouse protein CD154, a region determined from crystallography and site-directed mutational analysis to interact with CD40, the type I transmembrane protein found on antigen-presenting cells. CD154 is primarily expressed on activated T cells and CD40 – CD154 interactions are critical in the development and perpetuation of autoimmune disease, making CD40 signalling a target in autoimmunity. In addition to interacting with CD40, KGYY15 interacts with the integrins CD11a/CD18 and CD11b/CD18, and the resulting modulation of CD40-CD154 signalling may be more advantageous than complete inhibition. In vivo, KGYY15 is highly efficient in preventing hyperglycaemia in NOD mice that spontaneously develop type 1 diabetes. KGYY15 can also reverse new-onset hyperglycaemia.

SKU: PP-410 Categories: ,

Additional information

Other Names

Mouse KGYY15, KGYY15 peptide

Three Letter Sequence

H-Val-Leu-Gln-Trp-Ala-Lys-Lys-Gly-Tyr-Tyr-Thr-Met-Lys-Ser-Asn-OH

Molecular Weight

1815.93

Molecular Formula

C84H129N21O22S

Sequence

VLQWAKKGYYTMKSN

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

KGYY15, PP-410, PP410, KGYY15 peptide, VLQWAKKGYYTMKSN