IRL 1620

£125.00 1mg

SKU: ER-020 Categories: ,

Highly selective endothelin B receptor agonist.

IRL 1620 is an N-succinylated endothelin-1 analogue which acts as a highly selective ETB endothelin receptor agonist, with Ki values of 0.016 and 1900 nM at ETB and ETA receptors respectively. IRL 1620 can also discriminate between two subpopulations of ETB receptors, and in vivo IRL 1620 can significantly reduce neurological and motor deficit as well as infarct volume in a pediatric rat model of cerebral ischemia.

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Additional information

Other Names

Suc-[Glu9,Ala11,15]-endothelin-1(8-21)

Three Letter Sequence

Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH

Molecular Weight

1820

Molecular Formula

C86H117N17O27

Sequence

Suc-DEEAVYFAHLDIIW

Solubility

Soluble to 0.70 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

Asp-1 is succinylated

Searchable Words

IRL-1620, IRL1620, IRL-1620, 142569-99-1, Suc-DEEAVYFAHLDIIW, DEEAVYFAHLDIIW, Suc-[Glu9,Ala11,15]-endothelin-1(8-21)