IRL 1620
£125.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Highly selective endothelin B receptor agonist.
IRL 1620 is an N-succinylated endothelin-1 analogue which acts as a highly selective ETB endothelin receptor agonist, with Ki values of 0.016 and 1900 nM at ETB and ETA receptors respectively. IRL 1620 can also discriminate between two subpopulations of ETB receptors, and in vivo IRL 1620 can significantly reduce neurological and motor deficit as well as infarct volume in a pediatric rat model of cerebral ischemia.
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Additional information
| Other Names | Suc-[Glu9,Ala11,15]-endothelin-1(8-21) |
|---|---|
| Three Letter Sequence | Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH |
| Molecular Weight | 1820 |
| Molecular Formula | C86H117N17O27 |
| Sequence | Suc-DEEAVYFAHLDIIW |
| Solubility | Soluble to 0.70 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Asp-1 is succinylated |
| Searchable Words | IRL-1620, IRL1620, IRL-1620, 142569-99-1, Suc-DEEAVYFAHLDIIW, DEEAVYFAHLDIIW, Suc-[Glu9,Ala11,15]-endothelin-1(8-21) |