IRBP (1-20) (Human)
£75.00 1mg
N-terminal fragment of the interphotoreceptor retinoid binding protein (IRBP).
IRBP (1-20) (human) is the 1 to 20 amino acid N-terminal fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP, also known as retinol binding protein-3 (RBP-3), is a 1264 amino acid residue glycolipoprotein residing in the interphotoreceptor matrix where it is the major extracellular retinoid-binding protein. IRBP is often the target of autoimmune attack and this is one of the leading causes of uveitis. IRBP peptide (1-20) (human) contains a major epitope for the H-2b haplotype and immunization with IRBP (1 20) (human) induces T-cell mediated experimental autoimmune uveoretinitis (EAU), a widely used rodent model of human disease.
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Additional information
| Three Letter Sequence | H-Gly-Pro-Thr-His-Leu-Phe-Gln-Pro-Ser-Leu- Val- Leu-Asp-Met-Ala-Lys-Val-Leu-Leu-Asp-OH |
|---|---|
| Molecular Weight | 2194.62 |
| Molecular Formula | C101H164N24O28S |
| Sequence | GPTHLFQPSLVLDMAKVLLD |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | IM-040, IM040, IRBP (1-20) (human), 298202-25-2, GPTHLFQPSLVLDMAKVLLD, H-GPTHLFQPSLVLDMAKVLLD-OH, experimental autoimmune uveoretinitis (EAU), epitope, immunology, human interphotoreceptor retinoid binding protein, IRBP, uveitogenic |