IGFBP-3 Peptide

£135.00 1mg

Blocks ?haluronan-CD44 signaling.

IGFBP-3 peptide is a peptide derived from the nuclear localization sequence within the heparin-binding domain of insulin like growth factor binding protein-3 (IGFBP-3), and corresponds to amino acids 215-232 of the full-length protein. Both this region and IGFBP-3 peptide bind to glycosaminoglycans including hyaluronan, and also have high affinity and specificity for the mitochondria derived peptide humanin, binding to it with a with a Kd of 120 nM compared with binding of 101 nM for the full-length protein. Both the IGFBP-3 protein and the synthetic IGFBP-3 peptide bind to hyaluronic acid and block its ability to interact with its receptor CD44, and using the synthetic IGFBP-3 peptide to bind hyaluronan inhibits viability of A549 lung cancer cells, an effect correlated with increased apoptosis.

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SKU: PP-420 Categories: ,

Additional information

Other Names

215-KKGFYKKKQCRPSKGRKR-232

Three Letter Sequence

H-Lys-Lys-Gly-Phe-Tyr-Lys-Lys-Lys-Gln-Cys-Arg-Pro-Ser-Lys-Gly-Arg-Lys-Arg-NH2

Molecular Weight

2221.32

Molecular Formula

C98H172N36O21S

Sequence

KKGFYKKKQCRPSKGRKR-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

PP-420, PP420, KKGFYKKKQCRPSKGRKR-NH2