Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Blocks ?haluronan-CD44 signaling.

IGFBP-3 peptide is a peptide derived from the nuclear localization sequence within the heparin-binding domain of insulin like growth factor binding protein-3 (IGFBP-3), and corresponds to amino acids 215-232 of the full-length protein. Both this region and IGFBP-3 peptide bind to glycosaminoglycans including hyaluronan, and also have high affinity and specificity for the mitochondria derived peptide humanin, binding to it with a with a Kd of 120 nM compared with binding of 101 nM for the full-length protein. Both the IGFBP-3 protein and the synthetic IGFBP-3 peptide bind to hyaluronic acid and block its ability to interact with its receptor CD44, and using the synthetic IGFBP-3 peptide to bind hyaluronan inhibits viability of A549 lung cancer cells, an effect correlated with increased apoptosis.

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