IDR 1002

£85.00 1mg

Innate defence regulator peptide.

IDR 1002 is a synthetic host defense peptide derivative with strong anti-inflammatory properties which was identified from a library of bactenecin derivatives. IDR 1002 is protective against the Gram-negative bacterial pathogen Escherichia coli with chemokine induction by IDR 1002 being mediated through a Gi-coupled receptor and the PI3K, NF-kappaB, and MAPK signalling pathways. IDR 1002 suppresses in vitro inflammatory responses in murine monocyte/macrophage cells challenged with TLR4 and TLR2 agonists, and reduces airway hyperresponsiveness and inflammation in a house dust mite challenged model of airway inflammation.

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SKU: AM-320 Categories: ,

Additional information

Other Names

Innate defense regulator peptide 1002

Three Letter Sequence

H-Val-Gln-Arg-Trp-Leu-Ile-Val-Trp-Arg-Ile-Arg-Lys-NH2

Molecular Weight

1652.06

Molecular Formula

C79H130N26O13

Sequence

VQRWLIVWRIRK-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

AM-320, IDR 1002, 1224095-25-3, VQRWLIVWRIRK-NH2, Innate defense regulator peptide 1002, AM320