Hoe 140
£175.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Bradykinin B2 receptor antagonist.
Hoe 140, also known as icatibant, is a potent and selective bradykinin B2 receptor antagonist with a pA2 of 9.04. Hoe 140 also inhibits aminopeptidase N with a Ki of 9.1 μM. Hoe 140 is antinociceptive and anti-inflammatory in a number of acute nociceptive animal models.
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Additional information
| Other Names | Icatibant |
|---|---|
| Three Letter Sequence | H-(D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Oic-Arg-OH |
| Molecular Weight | 1304.5 |
| Molecular Formula | C59H89N19O13S |
| Sequence | RRPXGXSXXR |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Arg-1 is D-Arg, X-4 is Hyp, X-6 is Thi, X-8 is D-Tic, X-9 is Oic |
| Searchable Words | PN-090, icatibant, Hoe 140, bradykinin, B2, antinociceptive, 130308-48-4, PN-090, PN090 |