Hoe 140
£175.00 1mg
Bradykinin B2 receptor antagonist.
Hoe 140, also known as icatibant, is a potent and selective bradykinin B2 receptor antagonist with a pA2 of 9.04. Hoe 140 also inhibits aminopeptidase N with a Ki of 9.1 μM. Hoe 140 is antinociceptive and anti-inflammatory in a number of acute nociceptive animal models.
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Additional information
| Other Names | Icatibant |
|---|---|
| Three Letter Sequence | H-(D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Oic-Arg-OH |
| Molecular Weight | 1304.5 |
| Molecular Formula | C59H89N19O13S |
| Sequence | RRPXGXSXXR |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Arg-1 is D-Arg, X-4 is Hyp, X-6 is Thi, X-8 is D-Tic, X-9 is Oic |
| Searchable Words | PN-090, icatibant, Hoe 140, bradykinin, B2, antinociceptive, 130308-48-4, PN-090, PN090 |