Hoe 140

£175.00 1mg

Bradykinin B2 receptor antagonist.

Hoe 140, also known as icatibant, is a potent and selective bradykinin B2 receptor antagonist with a pA2 of 9.04. Hoe 140 also inhibits aminopeptidase N with a Ki of 9.1 μM. Hoe 140 is antinociceptive and anti-inflammatory in a number of acute nociceptive animal models.

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SKU: PN-090 Categories: ,

Additional information

Other Names

Icatibant

Three Letter Sequence

H-(D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Oic-Arg-OH

Molecular Weight

1304.5

Molecular Formula

C59H89N19O13S

Sequence

RRPXGXSXXR

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

Arg-1 is D-Arg, X-4 is Hyp, X-6 is Thi, X-8 is D-Tic, X-9 is Oic

Searchable Words

PN-090, icatibant, Hoe 140, bradykinin, B2, antinociceptive, 130308-48-4, PN-090, PN090