Antimicrobial peptide found in saliva.

Histatin 5 is a 24 amino acid histidine-rich cationic salivary peptide, formed with histatin 8 from post-translational cleavage of histatin 3. Histatins function as antimicrobial peptides and are important components of the innate immune system. Histatin 5 has broad spectrum antimicrobial action including activity against gram positive and gram negative bacteria, and fungi including Candida albicans and Aspergillus fumigans. Histatin 5 antifungal activity is caused by disruption to mitochondrial respiration through reactive oxygen species (ROS) production.

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