Hc-CATH

£175.00 1mg

Cathelicidin from sea snake .

Hc-CATH is a cathelicidin from the venom of the sea snake Hydrophis cyanocinctus, unusual in being derived from a marine reptile rather than a vertebrate. Hc-CATH possesses potent broad-spectrum antimicrobial activity, acting through disruption of cell membranes and lysis of bacterial cells, while showing low cytotoxicity toward mammalian cells. Hc-CATH also exhibits potent anti-inflammatory activity, in vitro inhibiting LPS-induced production of nitric oxide and pro-inflammatory cytokines, and in vivo significantly reducing the bacterial load and inflammation in mouse models of intraperitoneal and respiratory infection. Hc-CATH confers protection against ZIKV infection and has preventative and therapeutic efficacy in pregnant mice. Hc-CATH decreases the susceptibility of host cells to ZIKV by downregulating expression of AXL, a TAM (TYRO3, AXL and MERTK) family kinase receptor that mediates ZIKV infection, and also directly inactivates ZIKV particles by disrupting the viral membrane.

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SKU: AM-380 Categories: ,

Additional information

Other Names

Sea snake cathelicidin

Three Letter Sequence

H-Lys-Phe-Phe-Lys-Arg-Leu-Leu-Lys-Ser-Val-Arg-Arg-Ala-Val-Lys-Lys-Phe-Arg-Lys-Lys-Pro-Arg-Leu-Ile-Gly-Leu-Ser-Thr-Leu-Leu-OH

Molecular Weight

3626.33

Molecular Formula

C171H300N52O34

Sequence

KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL

Solubility

Soluble DMSO

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL, AM-380, AM380, Hc-CATH, Sea snake cathelicidin