Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Endogenous proatherosclerotic peptide hormone.

GIP_HUMAN[22-51] is a potent proatherosclerotic peptide hormone which has a common precursor with glucose-dependent insulinotropic polypeptide (GIP). Chronic infusion of GIP_HUMAN[22-51] into ApoE ??/ ?? mice accelerates the development of aortic atherosclerotic lesions and it also increases the serum concentrations of many inflammatory and proatherogenic proteins, and induces IκB-? degradation and nuclear translocation of NF-κB in human vascular endothelial cells and macrophages. GIP_HUMAN[22-51}] can also be labelled with 5-carboxyfluorescein and stable isotope labelled, please inquire.