Fz7-21

£99.00 1mg

Selective FZD7 antagonist.

Fz7-21 is a peptide identified from a phage library that impairs the function of Frizzled 7 (FZD7) in Wnt -catenin signalling, binding to the FZD7 extracellular cysteine rich domain (CRD) and altering its conformation and the architecture of its lipid-binding groove. Fz7-21 antagonises Wnt -catenin signalling in HEK293 cells stimulated with exogenous WNT3A with an IC50 of 100 nM and also blocks WNT3A-mediated stabilization of ?-catenin in mouse L cells. FzD7-21 impairs stem cell function in intestinal organoids.

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SKU: FZ-010 Categories: ,

Additional information

Other Names

FZD7-binding peptide

Three Letter Sequence

Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- Met-Tyr-NH2

Molecular Weight

1796.05

Molecular Formula

C83H114N18O23S2

Sequence

Ac-LPSDDLEFWCHVMY-NH2

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N terminal acetyl, C terminal amide

Searchable Words

Fz7-21, Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-
Met-Tyr-NH2, 2247635-23-8, FZ-010, fz010