Fz7-21
£99.00 1mg
Selective FZD7 antagonist.
Fz7-21 is a peptide identified from a phage library that impairs the function of Frizzled 7 (FZD7) in Wnt -catenin signalling, binding to the FZD7 extracellular cysteine rich domain (CRD) and altering its conformation and the architecture of its lipid-binding groove. Fz7-21 antagonises Wnt -catenin signalling in HEK293 cells stimulated with exogenous WNT3A with an IC50 of 100 nM and also blocks WNT3A-mediated stabilization of ?-catenin in mouse L cells. FzD7-21 impairs stem cell function in intestinal organoids.
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Additional information
| Other Names | FZD7-binding peptide |
|---|---|
| Three Letter Sequence | Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- Met-Tyr-NH2 |
| Molecular Weight | 1796.05 |
| Molecular Formula | C83H114N18O23S2 |
| Sequence | Ac-LPSDDLEFWCHVMY-NH2 |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N terminal acetyl, C terminal amide |
| Searchable Words | Fz7-21, Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- |