F1

£175.00 1mg

Blocks the association of IKKbeta and NEMO.

F1 is a peptide derived from amino acids 46-60 of IkB kinase (IKK) interacting protein (IKIP) fused to a TAT cell penetrating peptide. F1 peptide specifically interacts with IKKalpha/beta to block association with the regulatory subunit NEMO, also known as
IKKgamma, thereby inhibiting the phosphorylation of IKKalpha/beta and the activation of NF-kB. F1 reduces LPS induced acute inflammation and attenuates Zymosan-induced acute arthritis in mice.

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SKU: PP-220 Categories: ,

Additional information

Other Names

F1 peptide, TAT-IKIP (46-60)

Three Letter Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Leu-Ser-Leu-Ala-Met-Thr-Leu-Gly-Leu-Ala-Trp-Leu-Val-Phe-OH

Molecular Weight

3189.91

Molecular Formula

C145H246N48O31S

Sequence

YGRKKRRQRRRLLSLAMTLGLAWLVF

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

F1, PP-220, PP220, YGRKKRRQRRRLLSLAMTLGLAWLVF