F1
£175.00 1mg
Blocks the association of IKKbeta and NEMO.
F1 is a peptide derived from amino acids 46-60 of IkB kinase (IKK) interacting protein (IKIP) fused to a TAT cell penetrating peptide. F1 peptide specifically interacts with IKKalpha/beta to block association with the regulatory subunit NEMO, also known as
IKKgamma, thereby inhibiting the phosphorylation of IKKalpha/beta and the activation of NF-kB. F1 reduces LPS induced acute inflammation and attenuates Zymosan-induced acute arthritis in mice.
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Additional information
| Other Names | F1 peptide, TAT-IKIP (46-60) |
|---|---|
| Three Letter Sequence | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Leu-Ser-Leu-Ala-Met-Thr-Leu-Gly-Leu-Ala-Trp-Leu-Val-Phe-OH |
| Molecular Weight | 3189.91 |
| Molecular Formula | C145H246N48O31S |
| Sequence | YGRKKRRQRRRLLSLAMTLGLAWLVF |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | F1, PP-220, PP220, YGRKKRRQRRRLLSLAMTLGLAWLVF |