Exendin-4 (5-39) amide

£195.00 1mg

SKU: GH-009 Categories: , ,

Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Glucagon like peptide 1 (GLP-1) receptor antagonist.

Exendin-4 (5-39) is an antagonist of glucagon-like peptide 1 (GLP-1) receptors. GLP-1 is a G protein-coupled receptor (GPCR) that shares sequence identity with other Family B receptors such as those for secretin, glucagon, and vasoactive intestinal peptide. Unlike the full length exendin-4, a GLP-1 agonist, exendin (5-39) antagonizes GLP-1 stimulated insulin release after food intake. Exendin (5-39) also modulates synaptic transmission via glutamate uptake in the dentate gyrus and improves memory impairment in ?-amyloid protein-treated rats.

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Additional information

Three Letter Sequence

H-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Molecular Weight

3806.2

Molecular Formula

C169H262N44O54S

Sequence

TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2

Solubility

Soluble in dilute acid

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

Exendin-4 (5-39), antagonist of glucagon-like peptide 1, GLP-1, H-TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2, TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2, GH-009, GH009