ERα17p

£125.00 1mg

GPER inverse agonist.

ERα17p is a GPER inverse agonist, corresponding to residues 295-311 of the human estrogen receptor  (ERα). ? This 295-311 region is targeted by post-translational modifications and is involved in the recruitment of Ca2+-calmodulin, Hsp70 and the ubiquitin-protein isopeptide ligase E6-associated protein (E6AP), an E3 ligase catalyzing the ubiquitination of ER9, as well as association with ERα. ERα17p triggers membrane-initiated pro-apoptotic events in both ERα-positive and -negative breast cancer cell lines with a preference for ERα-positive cancer cells, and induces a decrease of more than 50% of the size of triple-negative breast tumour xenografts. ERα17p also exerts GPER mediated anti-hyperalgesic and anti-inflammatory actions in mice.

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SKU: GE-010 Categories: ,

Additional information

Other Names

ERα 295-311

Three Letter Sequence

H-Pro-Leu-Met-Ile-Lys-Arg-Ser-Lys-Lys-Asn-Ser-Leu-Ala-Leu-Ser-Leu-Thr-OH

Molecular Weight

1899.13

Molecular Formula

C84H154N24O23S

Sequence

PLMIKRSKKNSLALSLT

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

GE-010, GE010, PLMIKRSKKNSLALSLT, ERα17p, ERα 295-311 fragment