EPI-X4
£135.00 1mg
Endogenous CXCR4 antagonist.
EPI-X4 (endogenous peptide inhibitor of CXCR4) is a fragment identified from a blood-derived peptide library, corresponding to residues 408 423 of human serum albumin (hSA). EPI-X4 is a highly specific endogenous CXCR4 antagonist which is evolutionarily conserved and generated from the albumin precursor by pH-regulated proteases under acidic conditions that are a hallmark of inflammation. EPI-X4 suppresses CXCR4 signalling and inhibits infection by CXCR4 tropic HIV-1 strains. EPI-X4 can also antagonize CXCL12-induced tumour cell migration, mobilise stem cells and suppress inflammatory responses in mice. EPI-X4 ?is abundant in the urine of patients with inflammatory kidney diseases and may serve as a biomarker.
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Additional information
| Other Names | Endogenous peptide inhibitor of CXCR4, hSA(408 “423) peptide |
|---|---|
| Three Letter Sequence | H-Leu-Val-Arg-Tyr-Thr-Lys-Lys-Val-Pro-Gln-Val-Ser-Thr-Pro-Thr-Leu-OH |
| Molecular Weight | 1830.2 |
| Molecular Formula | C84H144N22O23 |
| Sequence | LVRYTKKVPQVSTPTL |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | EPI-X4, CK-030, CK030, LVRYTKKVPQVSTPTL, Endogenous peptide inhibitor of CXCR4, hSA(408 “423) peptide |