EPI-X4

£135.00 1mg

Endogenous CXCR4 antagonist.

EPI-X4 (endogenous peptide inhibitor of CXCR4) is a fragment identified from a blood-derived peptide library, corresponding to residues 408 423 of human serum albumin (hSA). EPI-X4 is a highly specific endogenous CXCR4 antagonist which is evolutionarily conserved and generated from the albumin precursor by pH-regulated proteases under acidic conditions that are a hallmark of inflammation. EPI-X4 suppresses CXCR4 signalling and inhibits infection by CXCR4 tropic HIV-1 strains. EPI-X4 can also antagonize CXCL12-induced tumour cell migration, mobilise stem cells and suppress inflammatory responses in mice. EPI-X4 ?is abundant in the urine of patients with inflammatory kidney diseases and may serve as a biomarker.

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SKU: CK-030 Categories: , ,

Additional information

Other Names

Endogenous peptide inhibitor of CXCR4, hSA(408 “423) peptide

Three Letter Sequence

H-Leu-Val-Arg-Tyr-Thr-Lys-Lys-Val-Pro-Gln-Val-Ser-Thr-Pro-Thr-Leu-OH

Molecular Weight

1830.2

Molecular Formula

C84H144N22O23

Sequence

LVRYTKKVPQVSTPTL

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

EPI-X4, CK-030, CK030, LVRYTKKVPQVSTPTL, Endogenous peptide inhibitor of CXCR4, hSA(408 “423) peptide