Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Endogenous CXCR4 antagonist.

EPI-X4 (endogenous peptide inhibitor of CXCR4) is a fragment identified from a blood-derived peptide library, corresponding to residues 408 423 of human serum albumin (hSA). EPI-X4 is a highly specific endogenous CXCR4 antagonist which is evolutionarily conserved and generated from the albumin precursor by pH-regulated proteases under acidic conditions that are a hallmark of inflammation. EPI-X4 suppresses CXCR4 signalling and inhibits infection by CXCR4 tropic HIV-1 strains. EPI-X4 can also antagonize CXCL12-induced tumour cell migration, mobilise stem cells and suppress inflammatory responses in mice. EPI-X4 ?is abundant in the urine of patients with inflammatory kidney diseases and may serve as a biomarker.

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