E70K
£125.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Inhibits CXCL8-induced neutrophil transendothelial migration.
E70K, also known as peptide 2, is the C-terminal CXCL8 peptide fragment CXCL8 (54-72), with a glutamic acid (E) substituted at position 70 with lysine (K) to increase positive charge. Similarly to CXCL8 (54-72), E70K inhibits CXCL8-induced neutrophil transendothelial migration and provides a lead for further development of therapeutic inhibitors of neutrophil-mediated inflammation based on modulation of chemokine GAG binding.
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Additional information
| Other Names | Peptide 2 |
|---|---|
| Three Letter Sequence | Ac-Lys-Glu-Asn-Trp-Val-Gln-Arg-Val-Val-Glu-Lys-Phe-Leu-Lys-Arg-Ala-Lys-Asn-Ser-NH2 |
| Molecular Weight | 2400.81 |
| Molecular Formula | C108H178N34O28 |
| Sequence | Ac-KENWVQRVVEKFLKRAKNS-NH2 |
| Solubility | Soluble in physiological buffers including PBS (>1mg./mL). Soluble in DMSO as a stock solution. |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N terminal acetylation, C terminal amide |
| Searchable Words | E70K, peptide 2, C-terminal CXCL8 peptide fragment CXCL8 (54-72), neutrophil transendothelial migration, chemokine “GAG binding, IM-015, IM015 |