E70K
£125.00 1mg
Inhibits CXCL8-induced neutrophil transendothelial migration.
E70K, also known as peptide 2, is the C-terminal CXCL8 peptide fragment CXCL8 (54-72), with a glutamic acid (E) substituted at position 70 with lysine (K) to increase positive charge. Similarly to CXCL8 (54-72), E70K inhibits CXCL8-induced neutrophil transendothelial migration and provides a lead for further development of therapeutic inhibitors of neutrophil-mediated inflammation based on modulation of chemokine GAG binding.
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Additional information
| Other Names | Peptide 2 |
|---|---|
| Three Letter Sequence | Ac-Lys-Glu-Asn-Trp-Val-Gln-Arg-Val-Val-Glu-Lys-Phe-Leu-Lys-Arg-Ala-Lys-Asn-Ser-NH2 |
| Molecular Weight | 2400.81 |
| Molecular Formula | C108H178N34O28 |
| Sequence | Ac-KENWVQRVVEKFLKRAKNS-NH2 |
| Solubility | Soluble in physiological buffers including PBS (>1mg./mL). Soluble in DMSO as a stock solution. |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N terminal acetylation, C terminal amide |
| Searchable Words | E70K, peptide 2, C-terminal CXCL8 peptide fragment CXCL8 (54-72), neutrophil transendothelial migration, chemokine “GAG binding, IM-015, IM015 |