E70K

£125.00 1mg

Inhibits CXCL8-induced neutrophil transendothelial migration.

E70K, also known as peptide 2, is the C-terminal CXCL8 peptide fragment CXCL8 (54-72), with a glutamic acid (E) substituted at position 70 with lysine (K) to increase positive charge. Similarly to CXCL8 (54-72), E70K inhibits CXCL8-induced neutrophil transendothelial migration and provides a lead for further development of therapeutic inhibitors of neutrophil-mediated inflammation based on modulation of chemokine GAG binding.

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SKU: IM-015 Categories: ,

Additional information

Other Names

Peptide 2

Three Letter Sequence

Ac-Lys-Glu-Asn-Trp-Val-Gln-Arg-Val-Val-Glu-Lys-Phe-Leu-Lys-Arg-Ala-Lys-Asn-Ser-NH2

Molecular Weight

2400.81

Molecular Formula

C108H178N34O28

Sequence

Ac-KENWVQRVVEKFLKRAKNS-NH2

Solubility

Soluble in physiological buffers including PBS (>1mg./mL). Soluble in DMSO as a stock solution.

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N terminal acetylation, C terminal amide

Searchable Words

E70K, peptide 2, C-terminal CXCL8 peptide fragment CXCL8 (54-72), neutrophil transendothelial migration, chemokine “GAG binding, IM-015, IM015