Decanoyl-RVKR-CMK
£145.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Proprotein convertase inhibitor.
Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor which blocks the activity of all seven convertases, PC1, PC2, PC4, PACE4, PC5, PC7 and furin. Proprotein convertases are involved in generating bioactive peptides and activating several enzymes and growth factors in many physiological events so have important roles in some pathologies including viral infections and cancer. Decanoyl-RVKR-CMK abolishes proET-1 processing in endothelial cells and inhibits regulated secretion of the neuronal polypeptide VGF. Decanoyl-RVKR-CMK can also inhibit cleavage of the SARS-CoV-2 spike protein by furin and blocks viral cell entry with an IC50 of 57 nM in a plaque reduction assay.
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Additional information
| Other Names | dec-RVKR-cmk, Furin Inhibitor I, decanoyl-RVKR-chloromethylketone |
|---|---|
| Three Letter Sequence | Decanoyl-Arg-Val-Lys-Arg-CMK |
| Molecular Weight | 744.42 |
| Molecular Formula | C34H66ClN11O5 |
| Sequence | Decanoyl-RVKR-CMK |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Amino terminal decanoyl, acid terminal chlororomethylketone |
| Searchable Words | Decanoyl-RVKR-CMK, dec-RVKR-cmk, 150113-99-8, Furin Inhibitor I |