Decanoyl-RVKR-CMK

£145.00 1mg

Proprotein convertase inhibitor.

Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor which blocks the activity of all seven convertases, PC1, PC2, PC4, PACE4, PC5, PC7 and furin. Proprotein convertases are involved in generating bioactive peptides and activating several enzymes and growth factors in many physiological events so have important roles in some pathologies including viral infections and cancer. Decanoyl-RVKR-CMK abolishes proET-1 processing in endothelial cells and inhibits regulated secretion of the neuronal polypeptide VGF. Decanoyl-RVKR-CMK can also inhibit cleavage of the SARS-CoV-2 spike protein by furin and blocks viral cell entry with an IC50 of 57 nM in a plaque reduction assay.

Please contact us for availability.

SKU: OP-010 Categories: ,

Additional information

Other Names

dec-RVKR-cmk, Furin Inhibitor I, decanoyl-RVKR-chloromethylketone

Three Letter Sequence

Decanoyl-Arg-Val-Lys-Arg-CMK

Molecular Weight

744.42

Molecular Formula

C34H66ClN11O5

Sequence

Decanoyl-RVKR-CMK

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

Amino terminal decanoyl, acid terminal chlororomethylketone

Searchable Words

Decanoyl-RVKR-CMK, dec-RVKR-cmk, 150113-99-8, Furin Inhibitor I