DC432
£125.00 1mg
N-terminal methyltransferase1/2 (NTMT1/2) inhibitor, cell permeable.
DC432 is a cell permeable analogue of BM30, also available, the first potent peptidomimetic substrate competitive inhibitor of N-terminal methyltransferase1/2 (NTMT1/2), one of a family of enzymes which methylate the ?-N-terminal amines of proteins starting with the canonical X-P-K/R motif. DC432 has been made cell permeable by the addition of five arginine residues to BM30. DC432 decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells.
Please contact us for availability.
Additional information
| Three Letter Sequence | 4-Hydroxyphenylacetyl-Pro-Lys-Arg-Arg-Arg-Arg-Arg-Arg-NH2 |
|---|---|
| Molecular Weight | 1313.59 |
| Molecular Formula | C55H100N28O10 |
| Sequence | XPKRRRRRR-NH2 |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | We recommend storage desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C terminal amide, X is 4-hydroxyphenylacetyl |
| Searchable Words | DC432, peptidomimetic, substrate, inhibitor of N-terminal methyltransferase1/2, NTMT1/2, cell permeable, N-terminal methylation, EI-020, EI020 |