DC432

£125.00 1mg

N-terminal methyltransferase1/2 (NTMT1/2) inhibitor, cell permeable.

DC432 is a cell permeable analogue of BM30, also available, the first potent peptidomimetic substrate competitive inhibitor of N-terminal methyltransferase1/2 (NTMT1/2), one of a family of enzymes which methylate the ?-N-terminal amines of proteins starting with the canonical X-P-K/R motif. DC432 has been made cell permeable by the addition of five arginine residues to BM30. DC432 decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells.

Please contact us for availability.

SKU: EI-020 Categories: , ,

Additional information

Three Letter Sequence

4-Hydroxyphenylacetyl-Pro-Lys-Arg-Arg-Arg-Arg-Arg-Arg-NH2

Molecular Weight

1313.59

Molecular Formula

C55H100N28O10

Sequence

XPKRRRRRR-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

We recommend storage desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide, X is 4-hydroxyphenylacetyl

Searchable Words

DC432, peptidomimetic, substrate, inhibitor of N-terminal methyltransferase1/2, NTMT1/2, cell permeable, N-terminal methylation, EI-020, EI020