[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic polypeptide
£175.00 1mg
Potent and selective Y5 agonist.
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide is a potent and selective peptide agonist for the neuropeptide Y Y5 receptor , with IC50 values for inhibition of neuropeptide Y binding to human Y5, Y1, Y2 and Y4 receptors of 0.24, 530, > 500, and 51 nM respectively, and a Ki at Y5 of 0.1 – 0.15 nM. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide stimulates food intake in vivo.
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Additional information
| Other Names | [cPP1 “7,NPY19 “23,Ala31,Aib32,Gln34]hPP |
|---|---|
| Three Letter Sequence | H-Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH2 |
| Molecular Weight | 4207.67 |
| Molecular Formula | C183H281N57O54S2 |
| Sequence | GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | X = Aib, Tyr-36 = C-terminal amide |
| Searchable Words | GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY-NH2, GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY, 313988-89-5, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide, [cPP1 “7,NPY19 “23,Ala31,Aib32,Gln34]hPP, GPSQPTYPGDNATPEQMARYYSALRRYINMABRQRY-NH2 |