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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic polypeptide

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic polypeptide

£175.00 1mg

SKU: NY-010 Categories: , ,

Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Potent and selective Y5 agonist.

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide is a potent and selective peptide agonist for the neuropeptide Y Y5 receptor , with IC50 values for inhibition of neuropeptide Y binding to human Y5, Y1, Y2 and Y4 receptors of 0.24, 530, > 500, and 51 nM respectively, and a Ki at Y5 of  0.1 – 0.15 nM. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide stimulates food intake in vivo.

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Additional information

Other Names

[cPP1 “7,NPY19 “23,Ala31,Aib32,Gln34]hPP
Three Letter Sequence

H-Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH2
Molecular Weight

4207.67
Molecular Formula

C183H281N57O54S2
Sequence

GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY-NH2
Solubility

Soluble to 1 mg/ml in water
Appearance

Freeze dried solid
Storage

Store dry, frozen and in the dark
Purity

>95% by HPLC
Modifications

X = Aib, Tyr-36 = C-terminal amide
Searchable Words

GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY-NH2, GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY, 313988-89-5, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide, [cPP1 “7,NPY19 “23,Ala31,Aib32,Gln34]hPP, GPSQPTYPGDNATPEQMARYYSALRRYINMABRQRY-NH2