Cortistatin 14

£125.00 1mg

Endogenous somatostatin like neuropeptide.

Cortistatin 14 is an endogenous neuropeptide that has structural and functional similarities to somatostatin 14. Cortistatin 14 shows potency at all five somatostatin receptors (sst1 – sst5) and prevents somatostatin 14 from binding to them (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Cortistatin 14 has neuronal depressant and sleep-modulating properties and co-exists with GABA within the cortex and hippocampus. Cortistatin 14 also binds with much lower potency to the ghrelin and ?MRGPRX2 receptors.

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SKU: SS-020 Categories: ,

Additional information

Other Names

CST-14

Three Letter Sequence

H-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (disulfide bridge between cysteine 2 and cysteine 13)

Molecular Weight

1721.03

Molecular Formula

C81H113N19O19S2

Sequence

PCKNFFWKTFSSCK

Solubility

Soluble to 0.70 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

Disulfide bridge between cysteine 2 and cysteine 13

Searchable Words

Cortistatin 14, 193829-96-8, CST-14, PCKNFFWKTFSSCK, SS-020