Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Chemokine-like receptor 1 (CMKLR1) agonist.

Chemerin-9 is a nonapeptide corresponding to amino acids 149-157 of the C terminus of processed chemerin, which retains most of the agonist activity of the full-size protein towards the chemokine-like receptor 1 (CMKLR1) with an EC50 of 7.1 nM. Chemerin-9 significantly suppresses TNF-?-induced mRNA expression of adhesion and pro-inflammatory molecules in human umbilical vein endothelial cells (HUVECs) and significantly attenuates TNF-?-induced adhesion of THP1 monocytes and the macrophage inflammatory phenotype. In Apoe -/- mice, a 4-week infusion of chemerin-9 significantly decreases aortic atherosclerotic lesions.

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