Chemerin-9

£75.00 1mg

Chemokine-like receptor 1 (CMKLR1) agonist.

Chemerin-9 is a nonapeptide corresponding to amino acids 149-157 of the C terminus of processed chemerin, which retains most of the agonist activity of the full-size protein towards the chemokine-like receptor 1 (CMKLR1) with an EC50 of 7.1 nM. Chemerin-9 significantly suppresses TNF-?-induced mRNA expression of adhesion and pro-inflammatory molecules in human umbilical vein endothelial cells (HUVECs) and significantly attenuates TNF-?-induced adhesion of THP1 monocytes and the macrophage inflammatory phenotype. In Apoe -/- mice, a 4-week infusion of chemerin-9 significantly decreases aortic atherosclerotic lesions.

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SKU: CH-010 Categories: ,

Additional information

Other Names

Chemerin 149-157, Chemerin-9 (human), Chemerin C-terminal peptide

Three Letter Sequence

H-Tyr-Phe-Pro-Gly-Gln-Phe-Ala-Phe-Ser-OH

Molecular Weight

1063.18

Molecular Formula

C54H66N10O13

Sequence

YFPGQFAFS

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

Chemerin-9, Chemerin 9, YFPGQFAFS, 676367-27-4, CH-010, Chemerin 149-157