BM30

£85.00 1mg

N-terminal methyltransferase1/2 (NTMT1/2) inhibitor.

BM30 is the first potent peptidomimetic inhibitor for N-terminal methyltransferase1/2 (NTMT1/2). BM30 has a half-maximal inhibitory concentration of 0.89 0.10 μM, is a competitive inhibitor to the peptide substrate and is noncompetitive to the cofactor S-adenosylmethionine. BM30 exhibits over 100-fold selectivity for NTMT1/2 among a panel of 41 methyl transferases, showing great potential for high selectivity when targeting the peptide substrate binding site of NTMT1/2. Its cell-permeable analogue DC432 is also available, which can decrease the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells.

Please contact us for availability.

SKU: EI-010 Categories: ,

Additional information

Three Letter Sequence

4-Hydroxyphenylacetyl-Pro-Lys-Arg-NH2

Molecular Weight

532.64

Molecular Formula

C25H40N8O5

Sequence

XPKR-NH2

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

X is 4-hydroxyphenylacetyl, C terminal amide

Searchable Words

BM30, N-terminal methyltransferase1/2, NTMT1/2, EI-010, EI010