BAM (8-22)

£145.00 1mg

Potent agonist of sensory neuron specific receptors.

BAM (8-22), also known as bovine adrenal medulla 8-22, is an endogenous peptide that was first isolated from bovine adrenal medulla and is a potent agonist for sensory neuron specific receptors, primate-specific proteins that are exclusively expressed in primary sensory neurons, with EC50 values of 28 and 14 nM for SNSR3 and SNSR4 respectively. BAM (8-22) inhibits development of morphine tolerance in rats and exerts spinal analgesic effects by an interaction with NMDA receptors. It also blocks inflammatory pain, chemical pain and downregulates the expression of spinal c-fos gene in an opioid-independent manner. In humans BAM (8-22) produces itch and nociceptive sensations in a histamine independent manner.

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SKU: PN-100 Categories: ,

Additional information

Other Names

Bovine adrenal medulla (8-22)

Three Letter Sequence

H-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH

Molecular Weight

1971.2

Molecular Formula

C91H127N25O23S

Sequence

VGRPEWWMDYQKRYG

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried sold

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

BAM (8-22), bovine adrenal medulla 8-22, bovine adrenal medulla pain, 412961-36-5, VGRPEWWMDYQKRYG, H-VGRPEWWMDYQKRYG-OH, PN-100, PN100