ATI 2341

£125.00 1mg

CXCR4 allosteric agonist.

ATI 2341 is a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR) at which it is an allosteric agonist with an EC50 of 194 nM. ATI 2341 functions as a biased ligand, favouring Gi activation over G13. In contrast to the natural CXCR4 agonist, stromal cell-derived factor-1, ATI 2341 does not promote ?-arrestin recruitment. ATI 2341 induces chemotaxis in CXCR4 expressing cells in vitro and acts as a functional antagonist to mobilise polymorphonuclear neutrophils and hematopoietic stem and progenitor cells from bone marrow niche in both mice and non-human primates.

SKU: CK-010 Categories: ,

Additional information

Three Letter Sequence

Pal-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH

Molecular Weight

2256.82

Molecular Formula

C104H178N26O25S2

Sequence

Pal-MGYQKKLRSMTDKYRL

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N-terminal palmitoyl

Searchable Words

ATI 2341, MGYQKKLRSMTDKYRL, Pal-MGYQKKLRSMTDKYRL , 1337878-62-2