ATI 2341
£125.00 1mg
CXCR4 allosteric agonist.
ATI 2341 is a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR) at which it is an allosteric agonist with an EC50 of 194 nM. ATI 2341 functions as a biased ligand, favouring Gi activation over G13. In contrast to the natural CXCR4 agonist, stromal cell-derived factor-1, ATI 2341 does not promote ?-arrestin recruitment. ATI 2341 induces chemotaxis in CXCR4 expressing cells in vitro and acts as a functional antagonist to mobilise polymorphonuclear neutrophils and hematopoietic stem and progenitor cells from bone marrow niche in both mice and non-human primates.
Additional information
| Three Letter Sequence | Pal-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH |
|---|---|
| Molecular Weight | 2256.82 |
| Molecular Formula | C104H178N26O25S2 |
| Sequence | Pal-MGYQKKLRSMTDKYRL |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N-terminal palmitoyl |
| Searchable Words | ATI 2341, MGYQKKLRSMTDKYRL, Pal-MGYQKKLRSMTDKYRL , 1337878-62-2 |