Apelin 12
£55.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
C-terminal fragment of the 77 amino acid prepropeptide apelin.
Apelin 12 (A12) is a biologically active C-terminal fragment of the 77 amino acid prepropeptide apelin, which is also the precursor of apelin 13 and apelin 36. Apelin 12 lowers blood pressure via a nitric oxide-dependent mechanism and is involved in control of feeding through stimulation of cholecystokinin (CCK) secretion. Apelin 12 can also reduce infarct size (IS) and augment contractile function recovery in the heart of rodents after regional or global ischemia.
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Additional information
| Other Names | A12 |
|---|---|
| Three Letter Sequence | H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-OH |
| Molecular Weight | 1422.7 |
| Molecular Formula | C64H103N21O14S |
| Sequence | RPRLSHKGPMPF |
| Solubility | Soluble in physiological buffers including PBS (>1mg./mL). Soluble in DMSO as a stock solution. |
| Appearance | Freeze dried solid |
| Storage | Store dessicated, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | H-RPRLSHKGPMPF-OH, RPRLSHKGPMPF, 229961-08-4, Apelin 12, A12, C-terminal fragment, apelin, CS-020, CS020 |