Amylin (8-37) (Human)

£165.00 1mg

Amylin receptor antagonist.

Amylin (8-37) (human) is a peptide fragment of amylin with the first seven amino acids removed, including the disulphide bridge, that acts as an amylin receptor antagonist. Amylin (8-37) (human) inhibits osteoblast proliferation induced by full-length human amylin and has no agonist activity at amylin receptors. Amylin (8-37) (human) induces formation of polymorphic fibrils containing coiled and laterally-associated sheet structures and is cytotoxic to RINm5F islet -cells in vitro when used at a concentration of 25 M, an effect that is inversely correlated with mature fibril content.

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SKU: CG-050 Categories: ,

Additional information

Other Names

IAPP (8-37), Islet Amyloid Polypeptide (8-37) (human)

Three Letter Sequence

H-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2

Molecular Weight

3183.49

Molecular Formula

C138H216N42O45

Sequence

ATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH

Solubility

Soluble to 1 mg per ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

Amylin (8-37) (human), ATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH ‚‚, 135702-23-7, Islet Amyloid Polypeptide (8-37) (human), CG-050, CG050