Amylin (8-37) (human)
£165.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Amylin receptor antagonist.
Amylin (8-37) (human) is a peptide fragment of amylin with the first seven amino acids removed, including the disulphide bridge, that acts as an amylin receptor antagonist. Amylin (8-37) (human) inhibits osteoblast proliferation induced by full-length human amylin and has no agonist activity at amylin receptors. Amylin (8-37) (human) induces formation of polymorphic fibrils containing coiled and laterally-associated sheet structures and is cytotoxic to RINm5F islet -cells in vitro when used at a concentration of 25 M, an effect that is inversely correlated with mature fibril content.
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Additional information
| Other Names | IAPP (8-37), Islet Amyloid Polypeptide (8-37) (human) |
|---|---|
| Three Letter Sequence | H-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 |
| Molecular Weight | 3183.49 |
| Molecular Formula | C138H216N42O45 |
| Sequence | ATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH |
| Solubility | Soluble to 1 mg per ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C terminal amide |
| Searchable Words | Amylin (8-37) (human), ATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH ‚‚, 135702-23-7, Islet Amyloid Polypeptide (8-37) (human), CG-050, CG050 |