Amylin (8-37) (Human)
£165.00 1mg
Amylin receptor antagonist.
Amylin (8-37) (human) is a peptide fragment of amylin with the first seven amino acids removed, including the disulphide bridge, that acts as an amylin receptor antagonist. Amylin (8-37) (human) inhibits osteoblast proliferation induced by full-length human amylin and has no agonist activity at amylin receptors. Amylin (8-37) (human) induces formation of polymorphic fibrils containing coiled and laterally-associated sheet structures and is cytotoxic to RINm5F islet -cells in vitro when used at a concentration of 25 M, an effect that is inversely correlated with mature fibril content.
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Additional information
| Other Names | IAPP (8-37), Islet Amyloid Polypeptide (8-37) (human) |
|---|---|
| Three Letter Sequence | H-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 |
| Molecular Weight | 3183.49 |
| Molecular Formula | C138H216N42O45 |
| Sequence | ATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH |
| Solubility | Soluble to 1 mg per ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C terminal amide |
| Searchable Words | Amylin (8-37) (human), ATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH ‚‚, 135702-23-7, Islet Amyloid Polypeptide (8-37) (human), CG-050, CG050 |